What is domperidone? Domperidone (Motilium) is a medication generally used for controlling nausea and vomiting, dyspepsia (upset stomach), diabetic gastroparesis (poor stomach emptying which occurs in diabetics) and gastric reflux (heartburn). Unlike metoclopramide (Reglan), it does not enter the brain compartment to any appreciable degree and has few to no central nervous system effects (such […]