The Association Between Breastfeeding Duration and Cognitive Development Up to Age 14
by Anne Eglash MD, IBCLC, FABM
There is extensive evidence that breastfed children score higher on cognitive testing than those not breastfed, even after controlling for socioeconomic variables such as parental income, education, and occupation, but the research is still criticized for insufficient control of these confounders.
The UK Millennium Cohort Study (MCS) was designed to evaluate how much of the association between breastfeeding duration and child cognitive development is due to socio-economic factors and maternal cognitive scores. The MCS study recruited 18,818 children in the UK in 2000-2002 at approximately 9 months of age, and followed them until age 17, with cognitive evaluations at ages 3, 5, 7, 11, 14, and 17 years. All children were singletons born >37 weeks gestation.
Breastfeeding duration was grouped as ‘never BF’; <2 months; ≥ 2 and < 4 months; ≥ 4 months and < 6 months; ≥ 6 and < 12 months; ≥ 12 months.
The following confounders were measured among the mothers: social class, as measured by occupation; maternal education; gestational age at birth, maternal ethnicity; languages spoken in household; maternal partnership status; mother working outside the home; birth by cesarean; older siblings in the home; maternal age; alcohol and/or tobacco use during pregnancy; and maternal cognitive ability as measured by verbal ability testing.
Within the study population, 90% of the mothers were white, 25.9% had higher education, 47.5 had lower education, 44.2% were in the highest social class based on occupation, 57.3% were married, 64.3% never smoked, and 7.3% had heavy alcohol use in pregnancy.
It was clear that breastfed children scored higher on cognitive verbal and spatial scores, with higher scores associated with longer breastfeeding.
However, the researchers also found that children who breastfed longer were more likely to have a more educated mother from a higher social class who was non-smoking, married, older, and had higher cognitive scores.
- Adjusting for maternal social class and educational level explained ½ of the observed associations between breastfeeding and higher child cognition scores.
- Adjusting for all confounders, including maternal intelligence testing, did not erase the association between child cognition scores up to age 14 and breastfeeding duration.
- The association between breastfeeding duration and child cognitive scores was highest at age 5, and lowest at age 14.
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Abstract
Background
Breastfeeding duration is associated with improved cognitive development in children, but it is unclear whether this is a causal relationship or due to confounding. This study evaluates whether the observed association is explained by socioeconomic position (SEP) and maternal cognitive ability.
Methods
Data from 7,855 singletons born in 2000-2002 and followed up to age 14 years within the UK Millennium Cohort Study were analysed. Mothers reported breastfeeding duration, and children’s cognitive abilities were assessed at 5, 7, 11, and 14 years using validated measures. Standardised verbal (age 5 to 14) and spatial (age 5 to 11) cognitive scores were compared across breastfeeding duration groups using multivariable linear mixed-effects models (repeated outcome measures).
Results
At all ages, longer breastfeeding durations were associated with higher cognitive scores after accounting for the child’s own characteristics. Adjustment for SEP approximately halved the effect sizes. Further adjustment for maternal cognitive scores removed the remaining associations at age 5, but not at ages 7, 11 and 14 (e.g.: verbal scores, age 14; breastfed ≥ 12 months vs never breastfed: 0.26 SD; 95%CI: 0.18, 0.34).
Conclusion
The associations between breastfeeding duration and cognitive scores persist after adjusting for SEP and maternal cognitive ability, however the effect was modest.
The researchers found the greatest effect was seen at age 14, among children who breastfed for at least 12 months, while the least effect was at age 5.
This was a well-controlled study, and when we add this study to a meta-analyses on breastfeeding and cognition, it seems clear that breastfeeding duration is responsible for higher childhood cognitive scores although with limitations.
Nearly all studies on breastfeeding duration and childhood cognition have been done in high-income countries. The UK Millennium Cohort Study (MCS) was poorly represented by non-White ethnic groups, so these results may not be applied to all populations.
Why would breastfeeding be associated with higher childhood cognition? Biologically speaking, long chain polyunsaturated fatty acids and other micronutrients in breastmilk, including microRNAs, play a role in brain maturity, and the differences in brain maturity among breastfed infants has been visualized in functional MRI studies.
The authors acknowledge that there may be other factors that have not been measured, such as paternal education and intelligence, and the nutritional status of non-breastfed infants against whom breastfed children are compared. There may be a difference in cognitive scoring among non-breastfed children who received cow’s milk vs infant formula fortified with essential fatty acids.